Charlie Rose Brain Series 2 Episode 11: Pain

with David Borsook, Laurie Klein, David Julius, Allan Basbaum, Eric Kandel and Robert Dworkin
in Science & Health part of Charlie Rose: The Brain Series
on Friday, November 23, 2012 * * * * *

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Charlie Rose Brain Series 2 Episode 11: Pain with Eric Kandel of Columbia University; David Julius, University of California, San Francisco; Allan Basbaum, University of California, San Francisco; Robert Dworkin, University of Rochester Medical Center; David Borsook of Boston Children's Hospital; and Laurie Klein, nursing student at LSU

Watch previous episodes here

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Keywords:
nerves
RSD
CRPS
chronic pain
brain

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    1. bag_of_fire  05/10/2013 09:23 AM Report

      In my country, here lives billion of people, and many video portals are banned due to political concerns, including youtube. So my only chance to reach this educational series is from Charlierose. I wish it keep alive for a long while, so many people can elevate their awareness by understanding objectively of what make us as a bag of thinking fire.

    2. bag_of_fire  05/10/2013 09:10 AM Report

      Thank you, Thank you, Thank you for sharing these wonderful Charlie Rose Brain Series, they are the best I ever found from the web.

      Now I know the concept of God is not the only one hold the grand truth. The very smart men could do as good as the Singularity too. They actually create the story of God.

      I watched all those available clips, and to the remaining unreachable, I pat my own back and say to the rest longings: Dear thinkers, do not yearn in desire toward it, but wait till it reaches us. Our very own life experiences is the ultimate teacher of the unknown.

      Hum....

      Ok, I still yearn for the clip of Schizophrenia and Consciousness, if you please share...

    3. lilminks  03/17/2013 08:59 PM Report

      I have long been searching for a collaborative session of scientists to speak on the subject of pain. Thank you, thank you, thank you. I am now looking for a presentation of the molecular and cellular level. Any plans in the near future?

    4. Richard_DeBiase  01/03/2013 11:25 PM Report

      I am very sympathetic to those who need marijuana for medical purposes. There is no objective way of measuring pain. All a patient can do is describe their pain to their doctor. All pain diagnosis is self-diagnosis, therefore I would say all pain medication is essentially self-medication. If a person says they are in pain, and marijuana provides relief, then that seems completely consistent with the medically accepted treatment of pain.

    5. SharkswithfrikingLazers  11/30/2012 07:34 PM Report

      25 Years of Breakthroughs: Timeline

      http://bbrfoundation.org/25-years-of-breakthroughs-timeline

      You will see Eric Kandel under the year 2000.

      Time to make a donation:

      https://www.bbrfoundation.org/civicrm/contribute/transact?reset=1&id=1&ref=homepage-donate-callout

    6. SharkswithfrikingLazers  11/30/2012 07:23 PM Report

      Congressional testimony reveals 80% of world's pain pills are consumed in the United States. Yet, the United States has only 5% of the world's population.

      http://www.cnn.com/2012/11/14/health/gupta-accidental-overdose/index.html

      The most common scenario, he said, involves a man in his 40s or 50s who visits a doctor with a backache and walks out with a pain pill prescription. About three years later, typically, the man dies in his sleep from taking too many pills, or mixing them with alcohol.

      Dr. Sanja Gupta and Bill Clinton explore the epidemic death side of pain.

    7. RSDFighter  11/27/2012 09:12 PM Report

      Worldwide Awareness Campaign Please Help

      People and sites from around the world are coming together to turn November 2013 into International RSD Awareness Month, currently only America has a National Awareness Month.

      Please spare 5 1/2 mins to watch this video but be aware you may find some of the images disturbing.

      http://www.youtube.com/watch?v=MviVcjWZDts

      it is vital that you watch it to the end

      If you are newly diagnosed I strongly suggest you do not watch it.

      If you live in the UK please sign http://epetitions.direct.gov.uk/petitions/31344

      E-mail the link to your MP asking why since being informed on 30/10/2010 David Cameron, Nick Clegg and The DOH have refused to do anything about the situation.

      You can also send it to some members of the House of Lords.

      http://www.parliament.uk/mps-lords-and-offices/lords/

      No matter where you live in the world can you please sign here http://www.pledgebank.com/RSDCRPS

      http://you.38degrees.org.uk/petitions/worldwide-rsd-crps-awareness-campaign

      http://www.thepetitionsite.com/460/118/995/worldwide-rsdcrps-awareness-campaign/

      http://www.change.org/en-GB/petitions/goverments-worldwide-un-world-health-organisiation-find-the-mil lions-of-un-misdaignosed-rsd-crps-sufferers-across-the-world

      http://www.ipetitions.com/petition/worldwide-rsdcrps-awareness-campaign/

      http://www.gopetition.com/petitions/worldwide-rsd-crps-awareness-campaign.html

      http://www.activism.com/en_GB/petition/worldwide-rsd-crps-awareness-campaign/40439

      http://www.causes.com/causes/800617-worldwide-rsd-awareness-campaign/actions/1700679

      http://www.petitionbuzz.com/petitions/worldwidersdcrps

      http://www.petitiononline.com/RSDCRPS1/petition.html

      http://www.communityrun.org/petitions/worldwide-rsd-crps-awareness-campaign-1

      https://petitions.whitehouse.gov/petition/take-immediate-action-inform-medical-professionals-existenc e-rsdcrps-most-painful-incurable/SFkd2cS6

      If you live in another Country can you start your own petition and send the link to your own Politicians

      If you are willing to commit to spending 15mins a day for 4 weeks then 15mins a week to help spread this then please e-mail me on.

      RSDFighter@hotmail.co.uk or join me on facebook

      Kevin

    8. carolljlee  11/27/2012 06:42 PM Report

      I have trigeminal neuralgia (tn), a severe, often disabling facial pain disorder (from a birth defect, although for most the reason behind this disorder is not known or only theoretical). The trigeminal nerve, cranial nerve 5, is what allows you to feel touch in your face. Trigeminal neuralgia makes that touch excruciating, sometimes so sensitive to sensation even a wisp of hair or a slight breeze can set off lightning like, knife cutting pain that may last for only a few seconds although some people, as did I for many years, may have constant pain as well as spontaneous and triggered.)

      It is interesting that one of the major symptoms and signs of tn is that you cannot tolerate any touch to the area of the face involved. Often when people describe CRPS it sounds like trigeminla neuralgia throughout the body, which to me, a non medical person, may indicate the level of nerve involvement.

      It is so nice to hear a discussion of chronic pain not revolve around "it is psychological, a remnant of childhood trauma", a theory recently espoused by Drs. Gupta and Pinsky among others.

      I have had numerous brain surgeries for the pain. I have been left with facial paralysis and 'anaesthesia dolorosa' (ad), a phantom pain of the face.

      The anticonvulsant stops 'tics' from the ad. I am currently with a 100% experimental sensory cortical brain stimulator implant (I am the 13th person in world with this implant which they decided to no longer offer) This helped with my phantom pain. Unfortunately it failed a few months ago.

      The doctors talk about early intervention. One of the problems with that is for many people with chronic pain it is hard to find doctors who believe us or believe in the pain, something you don't find with other disorders/diseases. Laurie was very lucky to be diagnosed early on.

      It is my belief that one of the changes in the brain is that the brain refuses to forget the pain even after it may have been resolved - leading to phantom pain.

      I am so happy to hear these doctors discuss not only current therapies and theories but research that is continuing.

      The House of Representatives passed a National Pain Care Bill but the senate has repeatedly not acted on it. This proposed legislation calls for research, treatment, and education in pain management.

      When people such as yourself and your experts talk about the realities of chronic pain it helps to let others know that this exists, it is real, and needs treatment so that we can become re-enabled.

      Thank you.

      Carol Jay Levy, B.A., CH.t

      author A PAINED LIFE, a chronic pain journey

      Women In Pain Awareness Group

      https://www.facebook.com/?ref=home#!/groups/111961795481256/

      The Pained Life, 30 years, and counting.http://apainedlife.blogspot.com/

      accredited to the U.N. Convention on the Rights of Persons with Disabilities member U.N. NGO group, Persons With Disabilities

    9. voteforscout  11/26/2012 09:03 PM Report

      On Labor Day weekend of 2010, my ten-year-old daughter twisted her ankle while playing in our front yard. Though there was no evidence of serious injury at the time, the next day she was in excruciating pain. Within a few days, we noticed her foot had a purplish color to it. Fortunately, our pediatrician immediately recognized the symptoms and made the diagnosis of Reflex Sympathetic Dystrophy aka Complex Region Pain Syndrome. Her condition progressed rapidly and within six weeks not only was the skin peeling off her foot , but her foot was 20 degrees colder than the other foot. Her pain was debilitating. Fortunately, we were able to get her in the Lucile Packard Children's Hospital at Stanford where she underwent treatment for almost a month. Fortunately, she has made a full recovery, and she has yet to have any other episodes. One thing I'd like to ask one of the experts on your panel is the role of stress in causing this disorder in children. The psychologist at Stanford was very aggressive in trying to root out any dysfunctions in our family dynamics to which she could hang the blame for her disorder. This was devastating to us. It doesn't make sense because many children survive extremely stressful situations without their nervous systems going haywire.

      When I pursued this question with another doctor, he believed the CRPS was possibly caused by intellectual stress as opposed to physical or emotional stress. He said it often occurs in children with higher IQ's and has to do with the nervous system's tendency to over-analyze a minor injury on a psycho-physical level. I just can't wrap my my mind how either of these explanations would cause such a debilitating, pernicious disease in a healthy, happy young girl.

      Could you please forward my email to one of the experts on your panel? Though I don't expect them to respond, they may be interested in these stress theories we have be struggling with. Thank you.

      Also, she created a video at Stanford which chronicles her treatment there. Here is the URL: http://www.youtube.com/watch?v=LRFghJROHro