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SharkswithfrikingLazers 07/19/2012 02:12 AM Report
In 1984, 33-year-old Barry Marshall, frustrated by responses to his work, ingested Helicobacter pylori, and soon developed stomach pain, nausea, and vomiting -- all signs of the gastritis he had intended to induce.
Why?
His conviction that he was right and a sense of urgency surrounding the importance of reducing the burden of ulcers -- which affected about 10 percent of Americans at some point in life -- led him to famously use himself as an animal model.
An animal model--sounds familiar.
Nowadays, we know that most ulcers are caused by disruption in mucosal defense and not by excess acid.
Frustration or Doomed-to-Die or "necessity is the mother of invention" are not very scientific yet can produce great science.
SharkswithfrikingLazers 07/19/2012 01:58 AM Report
We were told it cost over a million dollars in 2008 to sequence a human genome.
Steve Jobs paid about $100K.
Now you can get it done for around $26K.
Is there a Moore's Law for sequencing? So in four years it might cost a couple of hundred dollars and perhaps those supercomputers they were using will then be called laptops in around the same time.
SharkswithfrikingLazers 07/19/2012 01:51 AM Report
“If we say we need research because this is a new idea, then why is it that rich people can even access it?” asked Wylie Burke, professor and chairwoman of the department of bioethics at the University of Washington.
In this regard, was this special treatment that others would never get or was this heroic action?
Was this like when Steve Jobs gamed the system for a liver transplant when he should not have gotten one with his pancreatic cancer.
http://www.slate.com/articles/health_and_science/human_nature/2011/01/how_did_steve_jobs_get_his_live r.html
SharkswithfrikingLazers 07/19/2012 01:45 AM Report
"The researchers on the project put other work aside for weeks, running one of the university’s 26 sequencing machines and supercomputer around the clock. And they found a culprit — a normal gene that was in overdrive, churning out huge amounts of a protein that appeared to be spurring the cancer’s growth.
Even better, there was a promising new drug that might shut down the malfunctioning gene — a drug that had been tested and approved only for advanced kidney cancer. Dr. Wartman became the first person ever to take it for leukemia."
So how about working backwards for the other cancers--give them this drug first to save time and money? Then find the gene.
SharkswithfrikingLazers 07/18/2012 08:11 PM Report
In the mail a check for $478. Then this segment on an incredibly exciting advancement using a supercomputer and our recently acquired genome knowledge all while experimenting on a "Dead Man Walking".
What a day. What a day. What a day!!!!
We got a total of $478 yesterday from Humana.
Our Congressman voted last week to repeal Obamacare so this is "manna from heaven".
(Robert Nozick famously references "manna from heaven" in a thought experiment about distributive justice.[58])
My fellow Americans are due $1.1 billion in refunds this summer under the Obamacare law.
(I forgave my Congressman for his attempt to repeal Obamacare (and my refund) but I am still mad about his Grover Norquist pledge.)