Charlie Rose Brain Series 2 Episode 8: Parkinson's Disease and Huntington's Disease

with Stanley B. Prusiner, Eric Kandel, Stanley Fahn, Allen Goorin, Sam Posey and Anne B. Young
in Science & Health part of Charlie Rose: The Brain Series
on Friday, June 15, 2012 * * * * *

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Charlie Rose Brain Series 2 Episode 8: Parkinson's Disease and Huntington's Disease with Eric Kandel of Columbia University, Stanley Fahn of Columbia University, Allen Goorin of Harvard University, Anne B. Young of Harvard University, Stanley B. Prusiner of University of California, and former race car driver Sam Posey

Watch previous episodes here

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Keywords:
Addictive
health
medicine
disorders
drugs
Parkinson’s
Huntington's
neurological
science
brain
Psychiatric

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    1. Wanderingdoc  08/24/2012 05:05 PM Report

      As I watch the show regarding Parkinson's disease I was reminded of the excitement that my neurologist colleagues had when the early treatments for Parkinson's became available. Hopefully this progress will continue.

    2. Wanderingdoc  08/24/2012 05:02 PM Report

      As a retired physician I was excited to learn about the latest evidence regarding the role of prions in these neurodegenerative diseases. I applaud your series on "the brain". It has been most engrossing. Thank you.

    3. Activebz  06/21/2012 08:39 PM Report

      Another superb show, including Charlie's comment that in science on can make 'a difference.' This is a part of TV at its best. I thank and commend all who make it possible.

    4. SharkswithfrikingLazers  06/21/2012 02:25 AM Report

      We are told that L-dopa is now the standard of treatment—high doses and several weeks.

      The side effects are great:

      http://health.nytimes.com/health/guides/disease/parkinsons-disease/levadopa-%28l-dopa%29.html

      Looks like with all those side effects that this disease is screaming for something new.

    5. SharkswithfrikingLazers  06/21/2012 02:12 AM Report

      I heard 10 CAG repeat diseases but this says only nine:

      http://en.wikipedia.org/wiki/Trinucleotide_repeat_disorder#CAG_Repeats

      http://en.wikipedia.org/wiki/Trinucleotide_repeat_disorder#Polyglutamine_.28PolyQ.29_Diseases

      Nine inherited neurodegenerative diseases are caused by the expansion of the CAG trinucleotide and polyQ tract.[6] Two examples are Huntington's disease and spinocerebellar ataxias.

      So now we are getting to the level of computer coding for disease, perhaps machine level coding.

    6. ShalomFreedman  06/19/2012 03:51 AM Report

      Charlie Rose is masterful in his preparation of and performance of these interviews enabling each of the experts to contribute in a meaningful way. I am sure for those who are deep in these subjects there are more unasked questions than could possibly be addressed on this program. But for providing a basic outline of what is happening in research on these two devastating illnesses this program was an outstanding public service.

    7. BENEZRAA  06/19/2012 01:34 AM Report

      SCIENCE, MEDICINE, COMPASSION, COURAGE, HUMBLENESS, AND HUMOR AT IT'S BEST.

      If only there were a second Mr. Rose and sponsors to develop a variety of science series' on such subjects as terraforming, the musculoskeletal system, the nervous system, the cardiovascular system, the skin system, food science and agricultural science, aquaculture -- oh, heck, I love it all!

    8. RJD  06/18/2012 08:16 PM Report

      I greatly enjoy the Brain series episodes. This episode on PD and Huntington's was particularly intresting to me. My mother suffered from PD for close to 50 years. She was diagnosed when she was about 30 and died last year at 78. She participated in drug trials in the 60s , underwent a Palidotimy ( wihich provided her with great relief - and she walked for the first time in years ) and then years later a DBS - with moderate success. It effected her life from every perspective and resulted in personality change. It was heartening to see these 2 men make great effort to lead a full life. And the scientific research is heartening. Thank you for bringing this wonderful series to tthe public.

    9. SharkswithfrikingLazers  06/18/2012 03:57 PM Report

      Yes indeed, "Why with age?"

      Collagen and elastin are structural proteins made and used in the human body.

      Collagen is found primarily in tendons, ligaments, and the connective tissue of skin, blood vessels, and lungs (I can feel the stiffness and these are breaking down with age).

      Elastin is found primarily in the artery walls, lungs, intestines, and skin. These proteins work in partnership in connective tissues (I can see my face sagging every morning).

      Perhaps Telomeres?

      Telomeres are small pieces of genetic material at the tips of your chromosomes that help keep your body's DNA working properly.

      Poorly functioning telomeres make it more difficult for the cells in your body to renew themselves.

      Telomeres that begin to shorten have been strongly linked to biological aging, and to conditions like heart disease, cancer, and overall mortality.

      Is the the answer to my decay research on elastin, collagen and telomeres as well as the answer to these diseases?