Charlie Rose Brain Series 2 Episode 6: Autism

with Gerald Fischbach, Matthew State, Eric Kandel, Alison Singer and Uta Frith
in Science & Health part of Charlie Rose: The Brain Series
on Friday, May 11, 2012 * * * * *

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Charlie Rose Brain Series 2 Episode 6: Autism with Eric Kandel of Columbia University, Gerald Fischbach of The Simons Foundation, Uta Frith of University College London, Matthew State of Yale University, and Alison Singer of the Autism Science Foundation

Watch previous episodes here

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Keywords:
science
Addictive
medicine
disorders
drugs
health
neurological
brain
autism

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  • Comments 17
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    1. sspinac1  08/21/2012 01:59 PM Report

      I have a 26 year old child with high functioning autism. I understand this program's purpose is to discuss the new breakthroughs and understanding of this disorder, but I do not feel that the true devastation of its impact was conveyed. Perhaps this is where language leaves off. Raising and advocating for someone with autism (even at its mildest form on the spectrum) is so overwhelming. It requires tremendous strength, financial resources, isolation, constant explanation...it can devastate the family members and close relations, friends, if any stay close throughout the child's life.

      As all parents with a child challenged with this disorder, I love my son and will do everything for him. But the toll it takes, the lives it touches and affects is profound. Perhaps a show detailing the challenges society as a whole faces in dealing with the disorder/s would be helpful.

    2. Melindak  07/16/2012 09:52 AM Report

      I have a daughter with high functioning Asperger's I was interested with the topic and learned a great deal in a short time. It answered a question about my immedate family as a child trying to understand how we had a servant asperger child and the other sibling with Paranoid Schizophrenia. The unfortunate thing is the advancement was so slow that my sister died with Asperger's and yet in the 60's the called it infantile Schizophrenia and she was hospitalized a few times. Also given Thorazen which further damaged her and her life ended with diabetes complications. Where the sister with schizophrenic has been finally hospitalized at 56yrs. when she doesn't still know she has a problem and refuses therupy and Medication.

      Anyway I was amazed with the guest and how they summerized so well what has taken a lifetime to achieve.

      I thank you for putting this program together and hope there will be an update in the future on this topic.

    3. MichaelGreen  06/17/2012 03:09 PM Report

      This was a very well put together show. I can I can relate as I am an uncle of a 13 year old whom has Aspergers.

      My name is Michael S. Green and I am from Boston. I would like to explain how magnets work and where they originate from. I would like you to visit my website at www.godbasedmagnetism.blogspot.com and view a copy of my free 13 page book, GOD BASED MAGNETISM.

      Also, coming soon THE HUMAN BODY - MAGNETS AND MUSCLES.

      Thank you.

      Respectfully,

      Michael S. Green

    4. furtive  05/30/2012 02:13 AM Report

      pallendo,

      are you the writer of the articles you linked?

      let's take mercury out of the equation, how do you explain the rise in autism since the late 1980's?

      there was no "epidemic" until then.

      it is a poison that caused it.

      artificial toxicities caused gulf war syndrome. there was no human pesticide before 1991.

      my intellectual curiousity comes from many sources; and i don't like the ad hominem attacks.

      when you don't have the truth on your side, you invalidate. now is that how you gain credibility?

      like Obama...never!

    5. pallendo  05/18/2012 10:56 AM Report

      Furtive,

      How can you honestly believe what you just typed? I could put a VERY long VERY drawn out argument against every statement you just put up, but instead, I will link to somebody who has spent countless hours consolidating refuting statements.

      http://blogs.discovermagazine.com/badastronomy/2012/05/15/big-picture-science-antivaxxers-and-updates /

      http://blogs.discovermagazine.com/badastronomy/2011/12/29/stop-antivaxxers-now/

      and, one for the "Autism is caused by Vaccinations" crowd: http://blogs.discovermagazine.com/badastronomy/2011/06/23/give-a-buck-for-autism-research/

    6. furtive  05/16/2012 12:28 PM Report

      How can YOU HONESTLY PRODUCE A PROGRAM ON AUTISM AND IGNORE IMMUNITY ISSUES?

      Autism has multiplied 100-fold since the early 1990's---no man or woman had children later in life before that date?

      It is down's syndrome that is the primary result of older parent defective pregnancies, not autism.

      That you never brought up that Autism is related to toxic MERCURY vaccines, similar to insecticide for children who cannot tolerate them, and you continued with the same FDA LINE OF IRRESPONSIBILITY, SPEAKS VOLUMES ABOUT YOUR AGENDA.

      This was PURPOSEFUL LYING BY OMISSION. "60 minutes" tried to tell the truth about controversy; YOU SHOULD EMULATE THEM!

      You prep your guests and evade it to stay with the government position.

      A good patriot would challenge government edicts, not become their mouthpiece.

      We all weren't born yesterday without Autism!!

      http://endoftheamericandream.com/archives/vaccines-and-autism-the-secret-that-you-are-not-supposed-to -know

    7. furtive  05/16/2012 12:28 PM Report

      How can YOU HONESTLY PRODUCE A PROGRAM ON AUTISM AND IGNORE IMMUNITY ISSUES?

      Autism has multiplied 100-fold since the early 1990's---no man or woman had children later in life before that date?

      It is down's syndrome that is the primary result of older parent defective pregnancies, not autism.

      That you never brought up that Autism is related to toxic MERCURY vaccines, similar to insecticide for children who cannot tolerate them, and you continued with the same FDA LINE OF IRRESPONSIBILITY, SPEAKS VOLUMES ABOUT YOUR AGENDA.

      This was PURPOSEFUL LYING BY OMISSION. "60 minutes" tried to tell the truth about controversy; YOU SHOULD EMULATE THEM!

      You prep your guests and evade it to stay with the government position.

      A good patriot would challenge government edicts, not become their mouthpiece.

      We all weren't born yesterday without Autism!!

      http://endoftheamericandream.com/archives/vaccines-and-autism-the-secret-that-you-are-not-supposed-to -know

    8. SharkswithfrikingLazers  05/15/2012 02:39 AM Report

      In terms of social behavior and language abilities, Williams syndrome is the opposite of autism.

      With Williams syndrome you are missing about twenty genes from chromosome #7. Twenty might not seem like many out of the 25,000 or so that it takes to make a human being, but they made a big difference in who someone is, what he loves, and what he can do.

      Seems like Autism, when studied next to Williams Syndrome, will provide many answers.

    9. SharkswithfrikingLazers  05/15/2012 02:24 AM Report

      Research suggests that having an older father may increase a child’s risk of autism. Children born to men 40 years old or older were almost six times more likely to have an autism spectrum disorder than those born to men younger than 30 years old.

      http://facts.randomhistory.com/2009/09/21_autism.html

      So these men over 40 may want to masturbate more.

      There's another way that orgasm might boost fertility. This one involves men. Sperm that sit around in the body for a week or more start to develop abnormalities that make them less effective at head-banging their way into the egg. British sexologist Roy Levin has speculated that this is perhaps why men evolved to be such enthusiastic and frequent masturbators. He said, "If I keep tossing myself off I get fresh sperm being made." Which I thought was an interesting idea, theory. So now you have an evolutionary excuse.

      (Laughter)

      http://www.ted.com/talks/mary_roach_10_things_you_didn_t_know_about_orgasm.html

    10. topazgirl  05/15/2012 02:18 AM Report

      ...Where is Gelles? ...Long time no see!...

    11. SharkswithfrikingLazers  05/15/2012 02:13 AM Report

      From the descriptions this sounds to me like "emotional deafness" and perhaps the lack of formation of what some describe as Ghandi neurons.

      Only sleeping four hours and having to do repetitive actions may be indicators of Serotonin issues.

    12. NoPardonforMichaelMilken  05/14/2012 05:53 PM Report

      Two days since Massah Jamie announced JP Morgan's $2 BILLION MISTAKE.

      Not one single syllable from Ole' Charlie. Clearly Ole' Charlie, a lawyer he, don't want to see Massah Jamie turn off the cash contributions to his show.

      Seems Andy Ross Suckup learned his Corporate Public Relations Skills from Ole' Silent Charlie.

    13. NoPardonforMichaelMilken  05/14/2012 05:51 PM Report

      Charlie's not sayin' a mumblin' word about JP Morgan's $2 Billion Screw Up.

      Clearly Ole' Charlie don't want to upset Massah Jamie.

    14. anne4444  05/14/2012 04:30 PM Report

      Thank you for sharing.

      The universe has much longer history than human race. Because it is immortal (a lot of time), many lessons (or mistakes) have been learnt in the past, therefore it has supreme intelligence.

      The illusion of this physical world is a part of journey of soul development to avoid destruction of the creation.

      The origin of this universe is pure consciousness. This consciousness created many levels of energy and our physical world.

    15. funFactsAboutMySnail  05/14/2012 04:30 PM Report

      An alternative explanation:

      Autism: The Eusocial Hominid Hypothesis

      ASDs (autism spectrum disorders) are hypothesized as one of many adaptive human cognitive variations that have been maintained in modern populations via multiple genetic and epigenetic mechanisms. Introgression from "archaic" hominids (adapted for less demanding social environments) is conjectured as the source of initial intraspecific heterogeneity because strict inclusive fitness does not adequately model the evolution of distinct, copy-number sensitive phenotypes within a freely reproducing population.

      Evidence is given of divergent encephalization and brain organization in the Neanderthal (including a ~1520 cc cranial capacity, larger than that of modern humans) to explain the origin of the autism subgroup characterized by abnormal brain growth.

      Autism and immune dysfunction are frequently comorbid. This supports an admixture model in light of the recent discovery that MHC alleles (genes linked to immune function, mate selection, neuronal "pruning," etc.) found in most modern human populations come from "archaic" hominids.

      Mitochondrial dysfunction, differential fetal androgen exposure, lung abnormalities, and hypomethylation/CNV due to hybridization are also presented as evidence.

      Read the paper here: https://docs.google.com/open?id=0B3dPqM3qgNSiY3p5TmFRMjhSekdyaV8wWUw0MTZiUQ

      Watch a short video introduction: https://www.youtube.com/watch?v=Jk_85vNaSMA

      Watch a 2-hour video presentation: https://www.youtube.com/watch?v=rjoYf4cKbYo

    16. Odnamra  05/14/2012 03:03 PM Report

      What is it with you and politics? This is a science video.

    17. REMant  05/14/2012 12:21 PM Report

      It's amazing the way these programs start well enough, but after 15-20 mins get completely derailed and chug off into tendentiousness.

      Personally I don't think what most people call autism is either a disorder or has any developmental aspect. "It" would seem to be only an intensification of often found differences between men and women, or rationalists and, for want of a better word, "socialists."

      The idea floated at the end, and now rather old-fashioned, that all mental illness involves unsociable defenses, is no more "obvious" than the Freudian idea it attempts to supplant, that it involves defense of the self. On this score, I have been re-reading some of the literature spawned by the early 20th c attack on Calvinism, where it is quite clear the liberal mind finds it difficult to cope with evidence that such stoicism was in fact extremely sociable, its alleged misdeeds the conduct rather of liberalism's antecedents, and any primitive sociability no where to be found outside of the Garden of Eden. The fact is that Protestantism as early as Ockham and Wyclif decried tyranny as much as it belabored character. It was after all the Holy Mother Church which excommunicated people and burned them at the stake.

      There are a great number of people, who can't seem to put themselves in other's places, or sympathize (which is not at all a new notion, nor the same as objectivity) and/or who do not use language as well as they do other things. No one is "normal." A case might be made for some sort of statistical social normality, tho to do so would, it appears, be considered by this group to be abnormal. Similarly, that some people are dishonest is no reason to live dishonestly, altho some "philosophers" (and a few Popes) have long made that case.

      Some of this behavior has to be the result of interaction rather than inheritance, esp given what we now know about genes, and that it is supposed by mothers to be a particular problem with boys has to be explained. Much of it, too, seems to be the same behavior we find in other mental conditions, particularly obsessions, such as "hoarding." Looking away when thinking has long been noticed and explained by localization theories.

      Certainly doctors should not assume that genetic structure ought to remain the same, and those who think it should ought to renew their acquaintance with Darwin, tho I suppose they would believe that merely underscores the case for a kind of medicinal realism. Perhaps there IS something in the water which causes autistic mutations, like something in the air killing bees, something that we could point to as abnormal, but it remains to be proved, and even then some other folks will still consider it part of God's plan.

      BTW, I don't feel mothers have been too cold, but too hot. That was a liberal response to J B Watson, who protested against increasing (and well-documented) sentimentalism in child-rearing, even if he engaged in a variation of it himself. Though these experts now seem to have decided to dismiss child-rearing altogether, the distinguishing characteristic of this sort of thinking in the past 200 years or so is police, and it is a rare child in this country, particularly in its affluent parts, who is not mothered to death, no matter what is said about the demise of family. Indeed, the more the family dissolves, the more policing seems to be undertaken, and the more fuss is made about loss of community and about normalcy, which is, incidentally, what the fascists were accused of. A glance at the history of education will serve to illustrate that. And this process, of course, also has larger political and economic aspects. Too much of what passes for social science today is in fact social engineering.