The Disordered Brain

with John Krakauer , John Donoghue, Eric Kandel, Mahlon DeLong and Nancy Bonini
in Science & Health part of Charlie Rose: The Brain Series
on Thursday, July 22, 2010 * * * * *

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On Episode Ten of the Charlie Rose Brain Series, a conversation about neurological disorders with John Donoghue of Brown University, Mahlon Delong of Emory University, Nancy Bonini of the University of Pennsylvania, John Krakauer of Columbia University, and Eric Kandel of Columbia University

Please stay tuned as we will resume The Charlie Rose Brain Series in the fall.

Watch previous episodes here

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Keywords:
mental illness
emotion
health care
Insurance
health
neurological
sickness
brain
schizophrenia

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  • Comments 12
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    1. c824767  08/25/2010 08:54 PM Report

      hahah !

      decision making.

      do i want to be a cheating scumbag with an ever growing bank account in the bahamas !

      looks like a lot of people do want that , hence the problems in the USA

    2. c824767  08/25/2010 08:45 PM Report

      could athletes use the brain = robot thing for training, their bodies would then not get tired.injured. i.e. ice dancing, slalom skiing etc.

    3. c824767  08/25/2010 06:26 PM Report

      we localize function but brain can re=assign function to new areas so what the heck

    4. Natural  07/31/2010 11:58 AM Report

      This was a fascinating program. It gives much hope to those who are suffering. I also appreciate the idea of bringing together people from different disciplines to find more answers. These therapies can really create miracles in many lives.

      However, one thing puzzles me. I have to say that I was dismayed by the lack of attention paid to what is going on in the rest of the body. One of my favorite expressions from a holistic physician is, "I've never seen a brain without a body, nor a body without a brain." One must evaluate the processes of the entire body - brain and all - to better understand disease and treatment. This is also true in mental illness. Often it is dysfunction in some other part of the body that is negatively affecting brain function. Nutrition, toxic exposures, and stress can also be factors.

      Thank you to these very dedicated research scientists for their incredible contributions. I am sure their work will advance and help countless people.

    5. Vazrakapars  07/30/2010 03:26 PM Report

      As always is your brain series weary educational please continue whit this kind of work in the future as well in purpose to in light your viewers about all the different impacts that the brain has on the human action as well as its anatomy.

      Quote lll many thanks to Dr Eric Kandel as well for investing his time for all the episodes that I have watched on your show

    6. doodah  07/26/2010 06:13 PM Report

      so uh,.. what's everybody trying to tell me?

    7. robdverity  07/23/2010 10:20 PM Report

      "He made Man in His Image," disorders my brain something awful. Particularly re a science program. Scientific proof abounds, eh? Wonder how many on the show would cringe at that assertion?

      Ego trumps insult! Our ego, god's insult. Or actually our ego and our insult of the concept-of-god.

      If god gets-off on killing as much as we do then he deserves the insulting comparison. Some believe he martyred his own son, which has to be one of the more degrading insults to anyone, regardless of whose image is ascribed.

    8. BENEZRAA  07/23/2010 06:30 PM Report

      SPELLING CORRECTIONS TO PREVIOUS POSTING:

      ALZHEIMERS (not Alzeheimers)

      GREEK philosopher (not Greed philosopher)

    9. BENEZRAA  07/23/2010 06:27 PM Report

      EXCELLENT PROGRAM REPORTING PROFOUND AND OPTIMISTIC ADVANCES IN NEUROSCIENCE AND NEUROENGINEERING AS PERTAIN TO BRAIN-COMPUTER-ROBOT INTERFACE TECHNOLOGY. I agree with Dr. Kandel that there is a need to apply such technology to treat a variety of "psychological" problems that with sufficient science may be better understood and treated along the various neural pathways by engineering advances. As far as more determined brain ailments are concerned, it has been shown on this program that such aliments as Alzeheimers and Stroke and Spinal Pathway Disruption may be treated or aided with advanced localized electrical brain stimulation or even with thought-to-computer-to-robot interface technology. With regards to the latter -- have experiments yet been conducted on patients suffering from Multiple Schlerosis? I have a close friend, an MS paraplegic, who painstakingly uses an extension device from his mouth to operate his computer keyboard and has no independent control of his wheelchair. MS sufferers might benefit greatly from thought-to-computer-to-robot technology.

      Thank you to all these scientists, whose work is so little appreciated by so many, people who have no concept as to the painstaking work required to move science from hypothesis to thesis. From the philosophic concept of the atom by a pre-Socratic Greed philosopher to the achievement of the first atomic tables of the elements in the mid-19th century, humble humanity slowly advances it's discoveries into the realm of God's Physical Laws. May these great scientists continue to probe and advance humanity into His Realm, as He made Man in His Image.

    10. robdverity  07/23/2010 04:28 PM Report

      With increasing amputees, prosthetics, PTSD, suicides, etc being prodigiously produced daily by our jingoistic political minds, there will be no shortage of material to apply these demonstrated talents.

      Perhaps a more meaningful area of the mind ripe for exploration and manipulation is the area that foments war and more wars, preemptive or otherwise. Its moral acreage so-to-speak. The need for brain trauma therapies and prosthetics (at least) would decrease.

      Or are they considered fodder?

    11. PeterMelzer  07/23/2010 02:47 PM Report

      I enjoyed watching this show very much. The positive effects of subthalamic electrical stimulation on functionality in Parkinson's disease are impressive, though we do not seem to understand precisely why the stimulus works.

      The potential of brain-controlled prostheses is fantastic. Temporary prostheses may help improve recovery of function after stroke. I am confident that robotic prostheses will thrive. We are very good at making our tools part of our mind. One day, we may even succeed in controlling machines through nerve cell endings directly (more here: http://brainmindinst.blogspot.com/2008/01/man-machine.html).

      The understanding of gene function in neurodegenerative diseases is yet another avenue that will provide useful therapies. Surprisingly, the stem cell therapies were not discussed.

      However, despite the enormous progress in research and medicine, the treatments presented in this show remain symptomatic, and I agree with Prof. Mahlon-DeLong that we may only be able to develop the most effective treatments, if we uncover the molecular and neurophysiological mechanisms engaged in the disease process and in recovery.

      In his concluding remarks, Prof. Kandel laments that only recently psychologists and psychiatrists have warmed up to the advances made in neuroscience. He suggests they should learn from the neurologists. The reason may be that we still understand little of the complex nerve cell interactions that underlie the disorders of the mind. It has been simpler and more practical in the past to develop hypotheses and theories of the mind without digging too deeply into the brain. We are only at the beginning of a new era in which our knowledge of the brain will be integrated with our ideas of the mind. Perhaps, we need to develop a novel philosophy of mind that combines the thoughts of Heidegger and Gadamer with our latest insights into brain function.

    12. REMant  07/23/2010 01:40 PM Report

      Instead of what was promised last month, all there was here, aside from relieving symptoms of clearly physical ailments, was plain old-fashioned behavior mod, which we've practiced for 50 yrs with absolutely no ethical justification. The two are not, as was suggested (actually pushed) by Dr Kandel, in any way connected. It is in no way science, but plain old-fashioned Whig or Progressive reform that skips over and ignores science, as much as it does dignity, privacy and freedom. I think as did Erving Goffman, R D Laing, Thomas Szasz, Michel Foucault, Philip Rieff, Christopher Lasch, Aldous Huxley, Anthony Burgess, Ken Kesey, et al, and Alexis de Tocqueville before them, that it is extremely dangerous. I challenge Dr Kandel to produce an episode on this question.

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